Molecular Evolution of Gas cavity in [ NiFeSe] Hydrogenases Resurrected in Silico
January 27, 2016
The research group, Takashi Tamura Ph.D. and his colleagues of Graduate School of Environmental and Life Science, Okayama University has recently established method of novel computational chemistry to reproduce a reliable three-dimensional structure based on amino acid sequence information obtained from the phylogenetic tree analysis.
The findings were published on Jan 28, 2016 in the Scientific Reports of science magazine in the United Kingdom.
www.nature.com/articles/srep19742
The research group discovered the nine kinds of hydrogenases in the genome information of existing sulfate-reducing bacteria sulfate, and located that the family of the selenium-containing hydrogenase is derived from the system of common ancestor which was routed in universal [NiFe] type.
Furthermore, the group found that the gene cluster which constitutes the translation device of the seleno- cysteine residue had been inherited with the molecular evolution of a [Ni Fe Se] hydrogenase.
The research group established novel computational chemistry technique by using supercomputer for the information of very reliable computational protein molecular structure in the bacteria.
As for these results of the research is the first results of research that it was able to describe sequence information calculated as a phylogenetic tree in as a meaningful 3-D structure biologically.
The results of research can expect to contribute to industry implementation such as the system analysis of the development, molecular evolution study of bacteria species, and the bio-fuel cell of the enzyme that can be adopted structural computational chemistry.
Contact information
Mototaka Senda
Director, Okayama University Silicon Valley Office
Organization for Research Promotion and Collaboration, Okayama University
2450 Peralta Blvd. #222
Fremont, CA 94536 USA
TEL & FAX 510.894.3067
Email: takasenda (a)oakayama-u.ac.jp
For inquiries, please contact us by replacing (a) with the @ mark.
Takashi Tamura, Ph. D.
Graduate School of Environmental and Life Science, Okayama University, Okayama Japan