■業績一覧
２０２４年 業績
-原著論文-
2023年
Komoto S, Noma K, Kato T, Kobayashi T, Nishiwaki N, Narusaka T, Sato H, Katsura Y, Kashima H, Kikuchi S, Ohara T, Tazawa H, Fujiwara T
Conventional Cancer Therapies Can Accelerate Malignant Potential of Cancer Cells by Activating Cancer-Associated Fibroblasts in Esophageal Cancer Models.
Cancers. 2023 May 30;15(11):2971.
Chen K, Gong W, Huang J, Yoshimura T, Wang JM.
Developmental and homeostatic signaling transmitted by the G-protein coupled receptor FPR2.
Int Immunopharmacol. 2023 May:118:110052.
Honma K, Kirihara S, Nakayama H, Fukuoka T, Ohara T, Kitamori K, Sato I, Hirohata S, Fujii M, Yamamoto S, Ran S, Watanabe S
Selective autophagy associated with iron overload aggravates non-alcoholic steatohepatitis via ferroptosis.
Experimental biology and medicine.2023 Jul;248(13):1112-1123.
Yoshimura T, Li C, Wang Y, Matsukawa A.
The chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2) is a promoter of breast cancer metastasis.
Cell Mol Immunol. 2023 Jul;20(7):714-738.
Huang J, Xu H, Lin S, Zhou Z, Li D, Zhang X, Yu M, Zhao R, Wang Y, Qian J, Li X, Li B, Wei C, Chen K, Yoshimura T, Wang JM.
New Genetic and Epigenetic Insight into the Chemokine System: The Latest Discoveries Moving Toward Precision Medicine.
Cell Mol Immunol. 2023 Jul;20(7):739-776.
Shinoda-Ito Y, Omori K, Ito T, Nakayama M, Ikeda A, Ito M, Ohara T, Takashiba S
Novel Iron Chelators, Super-Polyphenols, Show Antimicrobial Effects against Cariogenic Streptococcus mutans.
Antibiotics.2023 Oct 24;12(11):1562.
Hori N, Tazawa H, Li Y, Okura T, Kikuchi S, Kuroda S, Ohara T, Noma K, Nishizaki M, Urata Y, Kagawa S, Fujiwara T,
Intraperitoneal Administration of p53-armed Oncolytic Adenovirus Inhibits Peritoneal Metastasis of Diffuse-type Gastric Cancer Cells.
Anticancer research.2023 Nov;43(11):4809-4821.
Kawasaki K, Noma K, Kato T, Ohara T, Tanabe S, Takeda Y, Matsumoto H, Nishimura S, Kunitomo T, Akai M, Kobayashi T, Nishiwaki N, Kashima H, Maeda N, Kikuchi S, Tazawa H, Shirakawa Y, Fujiwara T
PD-L1-expressing cancer-associated fibroblasts induce tumor immunosuppression and contribute to poor clinical outcome in esophageal cancer.
Cancer immunology, immunotherapy.2023 Nov;72(11):3787-3802.
Chen K, McCulloch J, Das Neves R, Rodrigues G, Hsieh WT, Gong W, Yoshimura T, Huang J, O'hUigin C, Difilippantonio S, McCollum M, Jones G, Durum SK, Trinchieri G, Wang JM.
The beneficial effects of commensal E. coli for colon epithelial cell recovery are related with Formyl peptide receptor 2 (Fpr2) in epithelial cells.
Gut Pathog. 2023 Jun 15;15(1):28.
2024年
Nishimura A, Miyoshi T, Otsuka F, Matsukawa A.
Influence of the coronavirus disease 2019 pandemic on the post-graduate career paths of medical students: a cross-sectional study.
BMC Med Educ. 2024 Jan 10;24(1):55.
Satomi T, Ochi Y, Okihara T, Fujii H, Yoshida Y, Mominoki K, Hirayama H, Toyosawa J, Yamasaki Y, Kawano S, Kawahara Y, Okada H, Otsuka M, Matsukawa A.
Innovative submucosal injection solution for endoscopic resection with phosphorylated pullulan: A preclinical study.
Gastrointest Endosc. 2024 Jan 13:S0016-5107(24)00020-8.
Sun C, Matsukawa A.
Role of Macrophages in Liver Fibrosis.
Acta Med Okayama. 2024 Feb;78(1):1-8.
Matsubara K, Miyoshi K, Kawana S, Kubo Y, Shimizu D, Tomioka Y, Shiotani T, Yamamoto H, Tanaka S, Kurosaki T, Takeshi Kurosaki T, Ohara T, Okazaki M, Sugimoto S, Matsukawa A, Toyooka S
In vivo lung perfusion for prompt recovery from primary graft dysfunction after lung transplantation.
The Journal of heart and lung transplantation.2024 Feb;43(2):284-292.
Noumi T, Kimura S, Fushimi T, Sakamoto S, Nakamura K, Fushimi S, Ohara T, Mashimo S, Tao T, Watanabe T, Kishino D
Two autopsied gastric cancer cases of rare drug-induced pneumonia associated with nivolumab plus S-1 and oxaliplatin: a case report.
Journal of gastrointestinal oncology.2024 Feb 29;15(1):491-499.
Akai M, Noma K, Kato T, Nishimura S, Matsumoto H, Kawasaki K, Kunitomo T, Kobayashi T, Nishiwaki N, Kashima H, Kikuchi S, Ohara T, Tazawa H, Choyke P, Kobayashi H, Fujiwara T
Fibroblast activation protein-targeted near-infrared photoimmunotherapy depletes immunosuppressive cancer-associated fibroblasts and remodels local tumor immunity.
British journal of cancer. 2024 Jun;130(10):1647-1658.
-和文論文、著書-
2023年
藤澤 真義
胚中心進展性異形成(PTGC)
非腫瘍疾患病理アトラス リンパ組織
佐藤康晴, 竹内賢吾 編(分担執筆)
文光堂 2023年4月 (ISBN: 9784830604911)
大原 利章, 仁科勇太
高品質木質バイオマス燃料のためのローラー式圧搾法
木材情報5月号 日本木材総合情報センター 2023年
大原 利章
木質バイオマス燃料の製造を効率化する木を搾る技術の開発
クリーンエネルギー8月号 日本工業出版 2023年
２０２３年 業績
2022年
Miyahara H, Hasegawa K, Yashiro M, Ohara T, Fujisawa M, Yoshimura T, Matsukawa A, Tsukahara H.
Thioredoxin interacting protein protects mice from fasting induced liver steatosis by activating ER stress and its downstream signaling pathways.
Sci Rep 2022; 12. 4819.
Li C, Yoshimura T, Tian M, Wang Y, Kondo T, Yamamoto K, Fujisawa M, Ohara T, Sakaguchi M, Matsukawa A.
Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4T1 breast cancer.
Breast Cancer Res 2022; 24. 60.
Shimizu D, Okazaki M, Sugimoto S, Kinoshita R, Nakata K, Tanaka S, Hashimoto K, Miyoshi K, Yamane M, Matsukawa A, Sakaguchi M, Toyooka S.
Inhibiting S100A8/A9 attenuates airway obstruction in a mouse model of heterotopic tracheal transplantation.
Biochem Biophys Res Commun. 2022; 629. 86-94.
Nakata K, Okazaki M, Sakaue T, Kinoshita R, Komoda Y, Shimizu D, Yamamoto H, Tanaka S, Suzawa K, Shien K, Miyoshi K, Yamamoto H, Ohara T, Sugimoto S, Yamane M, Matsukawa A, Sakaguchi M, Toyooka S.
Functional Blockage of S100A8/A9 Ameliorates Ischemia-Reperfusion Injury in the Lung.
Bioengineering. 2022; 9. 673.
Nakai H, Inokoshi M, Nozaki K, Yoshihara K, Matsukawa A, Nagaoka N, Tonprasong W, Minakuchi S.
Osteoblast Response of Additively Manufactured Zirconia and Alumina-Toughened Zirconia. Materials. 2022; 15. 8685.
Kajiwara Y, Tazawa H, Yamada M, Kanaya N, Fushimi T, Kikuchi S, Kuroda S, Ohara T, Noma K, Yoshida R, Umeda Y, Urata Y, Kagawa S, Fujiwara T.
Oncolytic virus-mediated reducing of myeloid-derived suppressor cells enhances the efficacy of PD-L1 blockade in gemcitabine-resistant pancreatic cancer.
Cancer Immunol Immunother. 2022; 72. 1285–1300.
Ogawa T, Kikuchi S, Tabuchi M, Mitsui E, Une Y, Tazawa H, Kuroda S, Noma K, Ohara T, Kagawa S, Urata Y, Fujiwara T.
Modulation of p53 expression in cancer-associated fibroblasts prevents peritoneal metastasis of gastric cancer.
Mol Ther Oncolytics. 2022; 25. 249-261.
Mansour H, Afify S, Hassan G, Quora H, Nawara H, Zahra M, Du J, Monzur S, Ohara T, Seno A, Seno M.
A comparative study of metastatic potentials of three different cancer stem cell models.
Advances in Cancer Biology – Metastasis. 2022; 100062.
Sato H, Noma K, Ohara T, Kawasaki K, Akai M, Kobayashi T, Nishiwaki N, Narusaka T, Komoto S, Kashima H, Katsura Y, Kato T, Kikuchi S, Tazawa H, Kagawa S, Shirakawa Y, Kobayashi H, Fujiwara T.
Dual-targeted near-infrared photoimmunotherapy for esophageal cancer and cancer-associated fibroblasts in the tumor microenvironment.
Scientific reports 2022; 12. 20152.
2023年
Ohara T, Yuasa K, Kimura K, Nishina Y, Matsukawa A.
A novel mechanical plant compression system for biomass fuel and acquisition of squeezed liquid with water-soluble lignin as anti-virus materials.
Journal of Material Cycles and Waste Management, 2023; 249–257
Wang Y, Ohara T, Chen Y, Hamada Y, Li C, Fujisawa M, Yoshimura T, Matsukawa A.
Highly Metastatic Subpopulation of TNBC Cells Has Limited Iron Metabolism and Is a Target of Iron Chelators.
Cancers 2023; 15. 468.
Nishiwaki N, Noma K, Ohara T, Kunitomo T, Kawasaki K, Akai M, Kobayashi T, Narusaka T, Kashima H, Sato H, Komoto S, Kato T, Maeda N, Kikuchi S, Tanabe S, Tazawa H, Shirakawa Y, Fujiwara T
Overcoming cancer-associated fibroblast-induced immunosuppression by anti-interleukin-6 receptor antibody.
Cancer Immunol Immunother, 2023; Online ahead of print.
Ahmed MH, Yoshihara K, Nagaoka N, Yao C, Matsukawa A, Yoshida Y, Van Meerbeek B. Acrylamide monomers in universal adhesives.
Dent Mater.2023; 39. 246-259.
Chen K, Liang W, Yoshimura T, Gong W, Huang J, Difilippantonio S, Jones G, York J,Trinchieri G, Wang Y, Wang JM.
Mucosal Protection Against Infection, Inflammation, and Carcinogenesis.
Int. J. Gastroenterol. 2023; 7. 1-14.
Gao T, Yang X, Fujisawa M, Ohara T, Wang T, Tomonobu N, Sakaguchi M, Yoshimura T, Matsukawa A.
SPRED2: A Novel Regulator of Epithelial-Mesenchymal Transition and Stemness in Hepatocellular Carcinoma Cells.
Int J Mol Sci. 2023; 24. 4996.
Chen K, Gong W, Huang J, Yoshimura T, Wang JM.
Developmental and homeostatic signaling transmitted by the G-protein coupled receptor FPR2. Int Immunopharmacol 2023; 118. 110052.
Yoshimura T, Li C, Wang Y, Matsukawa A.
The chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2) is a promoter of breast cancer metastasis. Cell Mol Immunol; 2023 In press.
Huang J, Xu H, Lin S, Zhou Z, Li D, Zhang X, Yu M, Zhao R, Wang Y, Qian J, Li X, Li B, Wei C, Chen K, Yoshimura T, Wang JM.
New Genetic and Epigenetic Insight into the Chemokine System: The Latest Discoveries Moving Toward Precision Medicine.
Cell. Mol. Immunol. 2023; In press.
-和文論文、著書-
2022年
日野啓輔, 加藤淳二, 大原利章
【鉄と肝がん:肝胆相照らす】鉄から肝がんを考える
肝胆膵 84(4) 509-521, 2022
樫野かおり、上田武滋、松川昭博 皮膚原発paget病手術の６年後に判明した肛門管粘液癌の一例 日本皮膚科学会雑誌 第132巻第９号 Ｐ147-2153、2022
2023年
著書
藤澤 真義．胚中心進展性異形成(PTGC)．
「非腫瘍性疾患病理アトラス リンパ組織」, 佐藤 康晴, 竹内賢吾 編, 文光堂, 2023
２０２２年業績
2021年
Yamaguchi T, Yoshimura T, Ohara T, Fujisawa M, Tong G, Matsukawa A.
PolyI:C suppresses TGF-β1-induced Akt phosphorylation and reduces the motility of A549 lung carcinoma cells.
Mol Biol Rep 2021;48(9):6313-6321.
Nakata K, Okazaki M, Shimizu D, Suzawa K, Miyoshi K, Otani S, Yamamoto H, Sugimoto S, Yamane M, Ousaka D, Ohara T, Matsukawa A, Nishibori M, Toyooka S.
Protective effects of anti-HMGB1 monoclonal antibody on lung ischemia reperfusion injury in mice.
Biochem Biophys Res Commun 2021;573:164-170.
Imamura M, Li T, Li C, Fujisawa M, Mukaida N, Matsukawa A, Yoshimura T.
Crosstalk between Cancer Cells and Fibroblasts for the Production of Monocyte Chemoattractant Protein-1 in the Murine 4T1 Breast Cancer.
Curr Issues Mol Biol 2021;43(3):1726-1740.
Oda S, Fujisawa M, Chunning L, Ito T, Yamaguchi T, Yoshimura T, Matsukawa A. Expression of Spred2 in the urothelial tumorigenesis of the urinary bladder.
PLoS One 2021;16(11):e0254289.
Kagawa T, Matsumi Y, Aono H, Ohara T, Tazawa H, Shigeyasu K, Yano S, Takeda S, Komatsu Y, Hoffman RM, Fujiwara T, Kishimoto H.
Immuno-hyperthermia effected by antibody-conjugated nanoparticles selectively targets and eradicates individual cancer cells.
Cell Cycle 2021;20(13):1221-1230.
Matsumi Y, Kagawa T, Yano S, Tazawa H, Shigeyasu K, Takeda S, Ohara T, Aono H, Hoffman RM, Fujiwara T, Kishimoto H.
Hyperthermia generated by magnetic nanoparticles for effective treatment of disseminated peritoneal cancer in an orthotopic nude-mouse model.
Cell Cycle 2021;20(12):1122-1133.
Koichiro Yamamoto, Kaoru Nakamura, Hideharu Hagiya , FumioOtsuka
Candidemia in COVID-19 treated with corticosteroids and tocilizumab
Clin Case Rep 2021;9(9):e04858.
2022年
Shams R, Matsukawa A, Ochi Y, Ito Y, Miyatake H.
In-silico and in-cell hybrid selection of non-rapalog ligands to allosterically inhibit the kinase activity of mTORC1.
J Med Chem 2022 ;65(2):1329-1341.
Oo MW, Kawai H, Takabatake K, Tomida S, Eguchi T, Ono K, Shan Q, Ohara T, Yoshida S, Omori H, Sukegawa S, Nakano K, Okamoto K, Sasaki A, Nagatsuka H.
Resident stroma-secreted chemokine CCL2 governs myeloid-derived suppressor cells in the tumor microenvironment.
JCI Insight 2022;7(1):e148960.
Hassan G, Ohara T, Afify SM, Kumon K, Zahra MH, Fu X, Al Kadi M, Seno A, Salomon DS, Seno M.
Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways.
J Exp Clin Cancer Res 2022;41(1):29.
Matsumoto K, Ohara T, Fujisawa M, Takaki A, Takahara M, Kato H, Yoshida R, Umeda Y, Yagi T, Matsukawa A, Okada H.
Diagnostic Utility of the PD-L1 Immunostaining in Biopsy Specimens of Patients with Biliary Tract Neoplasms.
J Gastrointest Surg 2022. doi: 10.1007/s11605-021-05197-6.
Miyahara H, Hasegawa K, Yashiro M, Ohara T, Fujisawa M, Yoshimura T, Matsukawa A, Tsukahara H.
Thioredoxin interacting protein protects mice from fasting induced liver steatosis by activating ER stress and its downstream signaling pathways.
Sci Rep 2022;12(1):4819.
-和文論文-
2021年
戸田久美子、竹井絵梨、木下実穂、森田美智子、松川昭博、開原正展
細胞診断における簡易セルブロックの有用性
尾道市立病院医学雑誌 34(1), 13-18、2021
大原利章
透析業務の管理（安全担保） (2) AIによる透析室管理の具体
臨床透析 37(17) 1502-1506, 2021
